Mayors from the United States, including several associated with the Mississippi River Cities and Towns Initiative, were in Paris for the deliberations at COP21. As Mayor of St. Paul Chris Coleman wrote before the trip, “the stakes [connecting climate change to river health] could not be higher”. In Paris, the mayors from the Mississippi River valley found common cause with mayors from other river cities across the world, arguing that river basins merited increased attention as food-producing regions supporting billions of people worldwide.